Advantages and Disadvantages of Solid and Semi-solid dosage form

Definition of semi-solid dosage form:

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Advantages and Disadvantages of Solid and Semi-solid dosage form. Dosage forms come in many types, depending on the method of administration.

Solid dosage forms, semi-solid dosage forms, liquid dosage forms, and gaseous dosage forms are used for the treatment of the disease by various methods.

Solid dosage forms are the most significant dosage forms. It has one or more unit doses of medicament. Solid dosage can be administered in the form of tablets, capsules, powders, etc.

And of these, the tablet is one of the most commonly used in solid dosage forms.

Examples of Solid dosage form:

Chewable tablets, buccal tablets, film-coated, sublingual tablets, and effervescent tablets, hard-shelled capsules, soft gelatin capsules, troches, powders, suppositories, and pellets, etc.

Advantages of Solid dosage form:

  • A high precision, lowest variability, stable and accurate dosing.
  • The formulation is simpler than liquid and semi-solid dosage forms.
  • A strong onset of action.
  • Several medicines and excipients or ingredients can combine,
  • and making it easier for the patient to avoid having to administer multiple doses.
  • The liquid form of the drug can be easily converted into a solid form using a capsule.
  • These are easy for packaging, transport.
  • And does not require special conditions for storage.
  • Easy to swallow and can be attractive to children.
  • Simple to swallow with water.
  • Easy to divide it into parts.
  • It does not harm the gastrointestinal tract.
  • The unpleasant taste and odor of drugs can be masked using capsules and sugar coating for tablets.
  • It can be manufactured in custom sizes, shapes, and colors.
  • Protect the API from atmospheric conditions (moisture, temperature, and light, etc.)
  • Stable in chemical, physical, and microbiological properties.

Disadvantages of solid dosage form:

  • It is not easy to swallow, particularly for children, and the elderly.
  • And cannot be given to the unconscious patient.
  • They are difficult to prepare with an API that has slow dissolution rates, low solubility in water, low density, amorphous and high absorption in the gastrointestinal tract.
  • Several medicines can cause gastric irritation when administered in the form of a tablet.
  • Hygroscopic drugs are not suitable for solid forms.
  • Some patients feel the unpleasant taste and smell and avoid swallowing them.
  • Coating, encapsulation of tablets, and the complex process may increase production costs.
  • Some examples – Chewable tablets, buccal tablets, film-coated, sublingual tablets, and effervescent tablets, hard-shelled capsules, soft gelatin capsules, troches, powders, suppositories, and pellets, etc.

Advantages and Disadvantages of Solid and Semi-solid dosage form PDF-

Definition of semi-solid dosage form:

Semi-solid dosage forms are the topical dosage form used for therapeutic, protective, or cosmetic functions. It may be applied to the skin, nasal, vaginal, or rectal cavity treatment.

Examples of semi-solid dosage form:

Ointments, pastes, cream, plasters, gels and rigid foams etc.

Advantages of semi-solid dosage forms:

  • It can be applied directly to the affected area, it gives prolong the action, and does not need to be administered orally.
  • Convenient for unconscious patients or patients for whom oral administration is difficult (such as children and old people).
  • More stable in atmospheric conditions than liquid dosage forms and solid dosage forms.
  • Suitable for those APIs that are low-density, amorphous hygroscopic.
  • Different drugs and excipients or ingredients can be added together in a single dose.
  • Gives better adhesion and lasts long after application,
  • Hence the medicament gives longer action.
  • Washable after each use.
  • Used externally, thereby decreased the risk of side effects.
  • Does not harm the gastrointestinal tract.
  • More convenient for patients than other forms of drug administration.
  • Suitable for medicines with a bitter taste.
  • The probability of side effects can be reduced with it.
  • Local action and Site-specific action of the drug on the affected area with it.

Disadvantages of semi-solid dosage forms:

  • It has no dose accuracy and needs to be applied directly.
  • Pharmaceutical creams, ointments, gels, suppositories, and paste are greasy and difficult to clean.
  • Less stable than the solid dosage form.
  • The base that used in the dose may be oxidized.
  • The need to apply with the fingers every time can cause contamination or other problems.
  • Some patients may become irritated or allergic.
  • Usually, a costly dosage because its manufacturing process is complex.
  • Physio-chemically less stable compared with the solid dosage form.
  • The accuracy can’t be measured.  

In the above article, You read about Advantages and Disadvantages of Solid and Semi-solid dosage form.

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